Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants

Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants.

We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration ([EC50]), and effective Hill coefficient, and explore the full spectrum of phenotypes that are accessible...

Supporting Information for Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants

Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants Supporting Information

Statistical mechanics of Monod-Wyman-Changeux (MWC) models.

The 50th anniversary of the classic Monod-Wyman-Changeux (MWC) model provides an opportunity to survey the broader conceptual and quantitative implications of this quintessential biophysical model. With the use of statistical mechanics, the mathematical implementation of the MWC concept links problems that seem otherwise to have no ostensible biological connection including ligand-receptor bind...

Characterizing Transcription Factor Induction using the Monod - Wyman - Changeux

11 Allosteric molecules serve as regulators of cellular activity across all domains of life. We present a general 12 theory of allosteric transcriptional regulation that permits quantitative predictions for how physiological 13 responses are tuned to environmental stimuli. To test the model’s predictive power, we apply it to the 14 specific case of the ubiquitous simple repression motif in bact...